Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives

Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives

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A series of diversely substituted chalcones derived from a quinoline scaffold, e.g.(E)-3-(2-chloroquinolin-3-yl)-1-(2-hydroxyphenyl) Originals High Rise Loose prop-2-en-1-one and its pyrimidine analogues e.g.

2-[2-amino-6-(2-chloroquinolin-3-yl)-5,6-dihydropyrimidin-4-yl]phenols have been prepared by condensation of 2-chloro-3-formyl quinoline with differently substituted 2-hydroxy acetophenones and further treatment with guanidine carbonate.All the newly synthesized compounds have been evaluated for their in vitro growth inhibitory activity against Algae Removers Escherichia coli, Pseudomonas vulgaris, Bacillus subtilis, Staphylococcus aureus, Staphylococcus typhi, Candida albicans, Aspergillus niger and Pseudomonas chrysogenum.